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  Product Citations  
  Apoptosis Detection Kits (Apo Logix FAM-FMK) Citations  
  Granzyme B activates procaspase-3 which signals a mitochondrial amplification loop for maximal apoptosis - Sunil S. Metkar, Baikun Wang, Michelle L. Ebbs,Jin H. Kim,Yong J. Lee, Srikumar M. Raja, Christopher J. Froelich - Journal of Cell Biology, Volume 160, Number 6, 875-885, 2003

Small-molecule XIAP inhibitors derepress downstream effector caspases and induce apoptosis of myeloid Leukemia cells - Carter, Gronda, Wang, et.al - Blood, May2005, Vol 105, No 10, pp4043-4050

Fenretinide enhances rituximab-induced cytotoxicity against B-cell lymphoma xenografts through a caspase dependant mechanism - Gopal, Pagel, et.al - Blood, May 2004, Vol 103, No 9, pp 3516-3520.

http://www.nature.com/leu/journal/v19/n1/full/2403560a.html 

Anoxia Is Necessary for Tumor Cell Toxicity Caused by a Low-Oxygen Environment - Papandreou, Krishna, Kaper, et.al - Cancer Research 65, 3171-3178, April 15, 2005


Thimerosal induces DNA Breaks, Caspase 3 Activation, Membrane Damage and Cell Death in Cultured Human Neurons and Fibroblasts - Baskin, Ngo, Didenko - Toxicological Sciences 74, 2003

IFN-{gamma} Induces Apoptosis in Ovarian Cancer Cells in Vivo and in Vitro - Wall, Burke, Barton, Smyth, Balkwill - Clinical Cancer Research Vol. 9, 2487-2496, July 2003

http://www.nature.com/onc/journal/v24/n24/full/1208542a.html

The removal of extracellular calcium: a novel mechanism underlying the recruitment of N-methyl-d-aspartate (NMDA) receptors in neurotoxicity - Xin, Zhao, Gang, et.al - European Journal of Neuroscience Vol 21, Issue 3, pg 622 - Feb 2005

Deficiency of the Cyclin Kinase inhibitor p21(WAF-1/CIP-1) Promotes Apoptosis of Activated/Memory T Cells, and inhibits spontaneous systemic Autoimmunity - J. Exp Medicine; Vol 199, Number 4, Feb 16 2004; 547-557


Ligand-independent redistribution of Fas (CD95) into lipid rafts mediates clonotypic T cell death - Jagan R Muppidi & Richard M Siegel - Nature Immunology 5, 182 - 189 (2004)

Attenuation of apoptosis in enterocytes by blocking potassium channels - Levitan, Makhina, et. al - Am J Physiol Gastrointest Liver Physiol (July 14, 2005).

Induction of Apoptosis Using Inhibitors of Lysophosphatidic Acid Acyltransferase-ß and Anti-CD20 Monoclonal Antibodies for Treatment of Human Non-Hodgkin's Lymphomas - John M. Pagel, Christian Laugen, Lynn Bonham, Robert C. Hackman, et.al - Clinical Cancer Research Vol. 11, 4857-4866, July 1, 2005. 

Inhibition of PI3K, mTOR and MEK signaling pathways promotes rapid apoptosis in B-lineage ALL in the presence of stromal cell support - Bertrand, Spengeman, Shelton, et.al - Leukemia (2005), 19, 98-102.

Tumor Suppressor DAL-I/4. IB and protein Methylation cooperate in inducing apoptosis MCF-7 breast cancer cells - Molecular Cancer 2006, 5:4
 
  Antibody specific Caspase 3 Detection Kit Citations (Apo Active 3)  
  The endoplasmic reticulum is the site of cholestrol-induced cytotoxicity in macrophages - Feng, Yao, Li, Devlin et al - Nature Cell Biology Vol 5, No 9, September 2003, pp 781-792

Deficiency of the Cyclin Kinase inhibitor p21(WAF-1/CIP-1) Promotes Apoptosis of Activated/Memory T Cells, and inhibits spontaneous systemic Autoimmunity - J. Exp Medicine; Vol 199, Number 4, Feb 16 2004; 547-557

Melanin acts as a potent UVB photosensitizer to cause an atypical mode of cell death in murine skin - Seiji Takeuchi, Wengeng Zhang, Kazumasa Wakamatsu, Shosuke Ito,Vincent J. Hearing, Kenneth H. Kraemer and Douglas E. Brash - PNAS U S A. 2004 October 19; 101(42): 15076–15081

Enhanced growth inhibition of squamous cell carcinoma of the head and neck by combination therapy of paclitaxel and opioid growth factor - Patricia McLaughlin, Jeffrey Jaglowski, et al - International Journal of Oncology 26: 809-816, 2005

Maternal Antibody Responses to the 52-kd SSA/Ro p200 Peptide and the Development of Fetal Conduction defects - Clancy, Buyon, Ikeda, et.al - Arthritis and Rheumatism Vol 52, No 10, October 2005, pp 3079-3086

 
  Mitochondria Membrane Potential Detection Kit Citations (JC1)  
  http://www.oldcitypublishing.com/FullText/JETOfulltext/JETO4.2fulltext/Yount.pdf

Deficiency of the Cyclin Kinase inhibitor p21(WAF-1/CIP-1) Promotes Apoptosis of Activated/Memory T Cells, and inhibits spontaneous systemic Autoimmunity - J. Exp Medicine; Vol 199, Number 4, Feb 16 2004; 547-557

Defects in Cell Growth Regulation by C18:0-Ceramide and Longevity Assurance Gene 1 (LAG1) in Human Head and Neck Squamous Cell Carcinomas (HNSCC) - Serap Koybasi, Can E. Senkal, Kamala Sundararaj, et al. - JBC Papers in Press. Published on August 17, 2004 as Manuscript M406920200

Tocotrienol-induced cytotoxicity is unrelated tomitochondrial stress apoptotic signaling in neoplastic mammary epithelial cells - Sumit J. Shah and Paul W. Sylvester - Biochem. Cell Biol. Vol. 83, 2005

β Adrenergic receptor-stimulated apoptosis in adult cardiac myocytes involves MMP-2-mediated disruption of β1 integrin signaling and mitochondrial pathway - Bindu Menon,Mahipal Singh, Robert Ross, Jennifer N. Johnson and Krishna Singh -   Am J Physiol Cell Physiol 290: C254-C261, 2006. First published September 7, 2005

SGLT-1-mediated glucose uptake protects intestinal epithelial cells against LPS-induced apoptosis and barrier defects: a novel cellular rescue mechanism? - Linda C. H. Yu Andrew N. Flynn, Jerrold R. Turner and Andre G. Buret- The FASEB Journal. 2005;19:1822-1835

Resveratrol-caused apoptosis of human prostate carcinoma LNCaP cells is mediated via modulation of phosphatidylinositol 3'-kinase/Akt pathway and Bcl-2 family proteins - Moammir H. Aziz,Minakshi Nihal, Vivian X. Fu, David F.Jarrard and N Ahmad - Mol Cancer Ther. 2006;5:1335-1341 

 
  Dual Sensor MitoCasp Citations  
 
 
 
 
Caspase-9-induced Mitochondrial disruption through cleavage of Anti-apoptotic BCL-2 family members - Chen, Guerrero, Huang, shabier et. al - Journal of Biological Chemistry Vol 282 No 46, pp 33888-33895, Nov 16 2007
 
OSU-03012, a Novel Celecoxib Derivative, Is Cytotoxic to Myeloma Cells and Acts through Multiple Mechanisms - Zhang, Suvannasankha, Crean, et.al - Clinical Cancer Research 13, pp 4750-4758, Aug 15, 2007
 
Galectin-3 but not galectin-1 induces mast cell death by oxidative stress and mitochondrial permeability transition - Yoshihiro Suzuki, Toshio Inoue, Tetsuro Yoshimaru and Chisei Ra - Biochimica et Biophysica Acta (BBA) - Molecular Cell Research - Vol 1783, issue 5, pp 924-934, 2008

 
  Caspase 3/7 High Throughout Assay - Apo 3/7 HTS Citations  
 
Identification of single-domain, Bax-specific intrabodies that confer resistance to mammalian cells against oxidative-stress-induced apoptosis - Deyzi Gueorguieva, Shenghua Li, Nicole Walsh, Amit Mukerji, Jamshid Tanha, and Siyaram Pandey - The FASEB Journal 2006
 
 
 
  Fluoro Catalase Detection Kit Citations  
  Expressions of HIF Prolyl Hydroxlase Isozymes in Growth Plate Chondrocytes: Relationship between maturation and Apoptotic Sensitivity - Terkhorn, Bohensky, Shapiro, et. al - Journal of Cellular Physiology 210:257-265 (2007)

3β-Hydroxysteroid-{Delta}24 Reductase Is a Hydrogen Peroxide Scavenger, Protecting Cells from Oxidative Stress-Induced Apoptosis - Xiuli Lu, Fukushi Kambe, Xia Cao, Yasuko Kozaki, Takahide Kaji, Takehisa Ishii and Hisao Seo - Endocrinology Vol. 149, No. 7 3267-3273, 2008.

 

  DNA Damage (ApossDNA) Detection Kit Citations  
  Overexpression of human truncated peroxisome proliferator-activated receptor {alpha} induces apoptosis in HL-1 cardiomyocytes -  Cardiovacular Research 2008 79(3):458-463 - Javier Beaumont Teresa Arias, Susana Ravassa and Javier Díez

Inhibition of Src reduces gemcitabine-induced cytotoxicity in human pancreatic cancer cell lines - Cancer Letters, Volume 260, Issue 1, Pages 155-162 - N. Ichihara, Y. Kubota, A. Kitanaka, T. Tanaka, T. Taminato

Inhibition of Eyes Absent Homolog 4 expression induces malignant peripheral nerve sheath tumor necrosis - S J Miller , Z D Lan , A Hardiman , J Wu , J J Kordich , D M Patmore , R S Hegde , T P Cripe , J A Cancelas , M H Collins & N Ratner - Oncogene 29, 368–379 (21 January 2010) | doi:10.1038/onc.2009.360

  Superoxide Dismutase Detection Kit Citations  
  Expressions of HIF Prolyl Hydroxlase Isozymes in Growth Plate Chondrocytes: Relationship between maturation and Apoptotic Sensitivity - Terkhorn, Bohensky, Shapiro, et. al - Journal of Cellular Physiology 210:257-265 (2007)  
  Fluoro H2O2 Detection Kit Citations  
  Deficiency of the Bax gene attenuates denervation-induced apoptosis - P. M. Siu and S. E. Alway - Apoptosis Journal Vol 11/No 6 June 2006  
  Fluoro Thiol Detection Kit Citations  
  Androgens Induce Dopaminergic Neurotoxicity via Caspase-3-Dependent Activation of Protein Kinase Cδ - Rebecca L. Cunningham, Andrea Giuffrida, and James L. Roberts - Endocrinology, doi:10.1210/en.2009-0640  
  ACT1 Assay for Cytotoxicity Citations  
 

Tetanus toxoid provides efficient T-cell help for the induction of HA-1H cytotoxic T cells - Britta Eiz-Vesper, Peter A. Horn, Claudia Daubert, Barbara Khattab, and Rainer Blasczyk - Transplantation and Cellular Engineering 2006

 
  Fluoro NAD/NADH Assay Citations  
  Ethanol disrupts chondrification of the neurocranial cartilages in medaka embryos without affecting aldehyde dehydrogenase 1A2 (Aldh1A2) promoter methylation- Yuhui Hu, Kristine L. Willett, Ikhlas A. Khan, Brian E. Scheffler and Asok K. Dasmahapatra - Comparitive Biochemistry and Physiology Part C: Toxicology & Pharmacology Vol 150, issue 4, November 2009, pp 495-502  
  Bioluminescence Cytotoxicity Assay Citations - aCella-TOX  
 
Henry Ogbomo, Anke Hahn, Janina Geiler, Martin Michaelis, Hans Wilhelm Doerr, Jindrich Cinatl Jr. NK sensitivity of Neuroblastoma cells determined by a highly sensitive coupled luminescent method;Biochemical and Biophysical Research Comunications 339 (2006) pp375-379. Click here to read the publication
 
Ogbomo H, et.al - Histone deacetylase inhibitors supress natural killer cell cytolytic activity - FEBS Lett (2007). Click here to read the publication
 
Identification of polymerase and processivity inhibitors of vaccinia DNA synthesis using a stepwise screening approach - Janice Elaine Y. Silverman, Mihai Ciustea, Abigail M. Druck Shudofsky, Florent Bender, Robert H. Shoemaker and Robert P. Ricciardi - Antiviral Research, In Press - June 20 2008

Resistance to Cytarabine induces the Up-regulation of NKG2D Ligands and enhances Natural Killer (NK) cell Lysis of Leukemic Cells - H Ogbomo, Martin Michaelis, Denise Klassert, Hans Wilhelm Doerr and Jindrich Cinatl Jr. - Neoplasia, Vol 10, No 12, pp 1402-1410, Dec 2008

Inhibition of human mesenchymal stem cell-derived adipogenesis by the environmental contaminant benzo(a)pyrene - Normand Podechard, Olivier Fardel, Michel Corolleur, Marc Bernard, and Valérie Lecureur - Toxicology In Vitro - Vol 23, Issue 5, Aug 2009 - In Press

Tumor cells infected with oncolytic influenza A virus prime natural killer cells for lysis of resistant tumor cells - Henry Ogbomo, Martin Michaelis, Janina Geiler, Marijke van Rikxoort, Thomas Muster, Andrej Egorov, Hans Wilhelm Doerr and Jindrich Cinatl Jr - Medical Microbiology and Immunology - 15 December 2009

Phase I Active Immunotherapy With Combination of Two Chimeric, Human Epidermal Growth Factor Receptor 2, B-Cell Epitopes Fused to a Promiscuous T-Cell Epitope in Patients With Metastatic and/or Recurrent Solid Tumors - Pravin T.P. Kaumaya, Kevin Chu Foy, Joan Garrett, Sharad V. Rawale, Daniele Vicari, Jennifer M. Thurmond, Tammy Lamb, Aruna Mani, Yahaira Kane, Catherine R. Balint, Donald Chalupa, Gregory A. Otterson, Charles L. Shapiro, Jeffrey M. Fowler, Michael R. Grever, Tanios S. Bekaii-Saab, William E. Carson, III - - Journal of Clinical Oncology, Vol 27, No 31 (November 1), 2009: pp. 5270-5277

A novel immunomodulatory mechanism of ribavirin in suppressing natural killer cell function - Henry Ogbomo, Martin Michaelis, Behric Altenbrandt, Hans Wilhelm Doerr, and Jindrich Cinatl Jr - Biochemical Pharmacology, Vol 79, issue 2, Jan 2010, pp 188-197
 
Corey, M. J. and Kinders, R. J. (2005) "Coupled Luminescent Methods in Drug Discovery: 3-Min Assays for Cytotoxicity and Phosphatase Activity" Drug Discovery Handbook, Ed. Shayne Cox Gad, published by John Wiley & Sons, Inc., pp. 689-731